A droplet acoustofluidic platform for time-controlled microbead-based reactions

Automation of a Multiplexed Microbead-based DNA Assay Platform

Microbead-based diagnostic technology has been explored in academia for over 30 years. As the technology matured, it became clear that this was a competitive platform for multiplexed pointof-care diagnostics for a number of different applications spanning from healthcare, border defense, food safety and environmental monitoring. To realize the benefits of this technology to Canada and the rest ...

Droplet-Based Microfluidic Scheme for Complex Chemical Reactions

Liquid flow in microfluidic channels typically occurs at low Reynolds numbers, such that the flow is purely laminar [Solomon et al. 2003; Oddy et al. 2001]. As a consequence, two or more streams of miscible fluids flowing side-by-side only mix by diffusion. Such a mixing is very slow and it would be difficult to perform chemical reactions within the typical length scales respectively time scale...

Continuous-flow In-droplet Magnetic Particle Separation in a Droplet-based Microfluidic Platform

ABSTRACT We demonstrate a droplet-based microfluidic device in which in-droplet magnetic bead separation is performed in continuous-flow. Two droplets containing different solution for the magnetic bead separation are generated in pair-wise manner. Sequential fusion of droplets occurs by a geometrical structure. The magnetic beads are deflected by externally applied magnetic force from one side...

Droplet Microfluidic Platform for Cell Electrofusion

A light-induced dielectrophoretic droplet manipulation platform.

We report on a light-actuated, droplet based microfluidic platform enabling two-dimensional (2D) droplet manipulation on an open chamber with a single-side, featureless photoconductive surface. The droplet actuation mechanism is based on recently demonstrated floating electrode optoelectronic tweezers (FEOET), which enable light-induced dielectrophoretic forces to manipulate aqueous droplets im...